Switching mechanism of a cyclic enzyme system: role as a "chemical diode"

Masahiro Okamoto, Toshio Sakai, Katsuya Hayashi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

We previously showed with computer simulations that cyclic enzyme systems play a role in metabolic switching events. In the present study, the detailed switching mechanism was investigated by clarifying the relationship between the switching mode and the phase-difference of two sinusoidal inputs to the cyclic enzyme system. The switching time could be predicted theoretically. Half-wave and full-wave rectifications were observed when the phase-difference of two sinusoidal inputs is equal to π. This result indicates the possibility that this cyclic enzyme system is available for use as a switching circuit (biochip) in a bio-computer.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBioSystems
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 1987

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

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