Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B–Z DNA Transition

Kensuke Kawara, Genichiro Tsuji, Yosuke Taniguchi, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The 2,13-dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B-DNA by the accompanying induction of its (P)-chirality together with the B-to-Z helicity change of the duplex DNA, [(dC-dG)3]2. The (P)-chirality of the bound 8 b, in turn, transitioned to the (M)-chirality according to the Z-helicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand.

Original languageEnglish
Pages (from-to)1763-1769
Number of pages7
JournalChemistry - A European Journal
Volume23
Issue number8
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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