Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B–Z DNA Transition

Kensuke Kawara; Genichiro Tsuji; Yosuke Taniguchi; Shigeki Sasaki

doi:10.1002/chem.201605276

Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B–Z DNA Transition

Kensuke Kawara, Genichiro Tsuji, Yosuke Taniguchi, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

The 2,13-dimethoxy[5]helicene–spermine ligand 8 b possesses an axial chirality. The racemic 8 b was bound to B-DNA by the accompanying induction of its (P)-chirality together with the B-to-Z helicity change of the duplex DNA, [(dC-dG)₃]₂. The (P)-chirality of the bound 8 b, in turn, transitioned to the (M)-chirality according to the Z-helicity of the DNA. These results illustrate the chirality synchronization between the DNA and the ligand.

Original language	English
Pages (from-to)	1763-1769
Number of pages	7
Journal	Chemistry - A European Journal
Volume	23
Issue number	8
DOIs	https://doi.org/10.1002/chem.201605276
Publication status	Published - Jan 1 2017

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All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

Cite this

Kawara, K., Tsuji, G., Taniguchi, Y., & Sasaki, S. (2017). Synchronized Chiral Induction between [5]Helicene–Spermine Ligand and B–Z DNA Transition. Chemistry - A European Journal, 23(8), 1763-1769. https://doi.org/10.1002/chem.201605276

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10.1002/chem.201605276