Synchronized oscillation of the segmentation clock gene in vertebrate development

Koichiro Uriu, Yoshihiro Morishita, Yoh Iwasa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In vertebrate somitogenesis, "segmentation clock" genes (her in zebrafish, hes in mouse, and hairy in chick) show oscillation, synchronized over nearby cells through intercellular interaction. In zebrafish, neighboring cells interact by Delta-Notch signaling to realize synchronization. Under Delta-Notch, however, a cell with a high expression of the segmentation clock gene tends to suppress its expression in adjacent cells, which might produce spatial heterogeneity instead of synchronized oscillation. Here we studied the conditions under which pre-somitic mesoderm cells show synchronized oscillation of gene expression mathematically. We adopted a model that explicitly considers the kinetics of the mRNA and proteins of the segmentation clock gene and cell-cell interaction via Delta-Notch signaling. From statistical study of a model with randomly generated parameters, we revealed how the likelihood that the system generates stable synchronized oscillation depends on the rate of each reaction in the gene-protein kinetics.

Original languageEnglish
Pages (from-to)207-229
Number of pages23
JournalJournal of Mathematical Biology
Volume61
Issue number2
DOIs
Publication statusPublished - Aug 1 2010

Fingerprint

Vertebrates
oscillation
Clocks
Segmentation
Genes
vertebrates
Oscillation
Gene
Cell
Notch
Zebrafish
genes
cells
Proteins
Kinetics
Danio rerio
Gene expression
Somatostatin-Secreting Cells
Mesoderm
Synchronization

All Science Journal Classification (ASJC) codes

  • Modelling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

Cite this

Synchronized oscillation of the segmentation clock gene in vertebrate development. / Uriu, Koichiro; Morishita, Yoshihiro; Iwasa, Yoh.

In: Journal of Mathematical Biology, Vol. 61, No. 2, 01.08.2010, p. 207-229.

Research output: Contribution to journalArticle

Uriu, Koichiro ; Morishita, Yoshihiro ; Iwasa, Yoh. / Synchronized oscillation of the segmentation clock gene in vertebrate development. In: Journal of Mathematical Biology. 2010 ; Vol. 61, No. 2. pp. 207-229.
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