TY - JOUR
T1 - Synchrony of auditory brain responses predicts behavioral ability to keep still in children with autism spectrum disorder
T2 - Auditory-evoked response in children with autism spectrum disorder
AU - Yoshimura, Yuko
AU - Kikuchi, Mitsuru
AU - Hiraishi, Hirotoshi
AU - Hasegawa, Chiaki
AU - Takahashi, Tetsuya
AU - Remijn, Gerard B.
AU - Oi, Manabu
AU - Munesue, Toshio
AU - Higashida, Haruhiro
AU - Minabe, Yoshio
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Young Scientists (B) (research number 24791206 ), the Center of Innovation Program from Japan Science and Technology Agency ( JST ), and the Strategic Research Program for Brain Sciences from MEXT , Japan. The authors declare no competing financial interests.
Publisher Copyright:
© 2016 The Authors
PY - 2016
Y1 - 2016
N2 - The auditory-evoked P1m, recorded by magnetoencephalography, reflects a central auditory processing ability in human children. One recent study revealed that asynchrony of P1m between the right and left hemispheres reflected a central auditory processing disorder (i.e., attention deficit hyperactivity disorder, ADHD) in children. However, to date, the relationship between auditory P1m right-left hemispheric synchronization and the comorbidity of hyperactivity in children with autism spectrum disorder (ASD) is unknown. In this study, based on a previous report of an asynchrony of P1m in children with ADHD, to clarify whether the P1m right-left hemispheric synchronization is related to the symptom of hyperactivity in children with ASD, we investigated the relationship between voice-evoked P1m right-left hemispheric synchronization and hyperactivity in children with ASD. In addition to synchronization, we investigated the right-left hemispheric lateralization. Our findings failed to demonstrate significant differences in these values between ASD children with and without the symptom of hyperactivity, which was evaluated using the Autism Diagnostic Observational Schedule, Generic (ADOS-G) subscale. However, there was a significant correlation between the degrees of hemispheric synchronization and the ability to keep still during 12-minute MEG recording periods. Our results also suggested that asynchrony in the bilateral brain auditory processing system is associated with ADHD-like symptoms in children with ASD.
AB - The auditory-evoked P1m, recorded by magnetoencephalography, reflects a central auditory processing ability in human children. One recent study revealed that asynchrony of P1m between the right and left hemispheres reflected a central auditory processing disorder (i.e., attention deficit hyperactivity disorder, ADHD) in children. However, to date, the relationship between auditory P1m right-left hemispheric synchronization and the comorbidity of hyperactivity in children with autism spectrum disorder (ASD) is unknown. In this study, based on a previous report of an asynchrony of P1m in children with ADHD, to clarify whether the P1m right-left hemispheric synchronization is related to the symptom of hyperactivity in children with ASD, we investigated the relationship between voice-evoked P1m right-left hemispheric synchronization and hyperactivity in children with ASD. In addition to synchronization, we investigated the right-left hemispheric lateralization. Our findings failed to demonstrate significant differences in these values between ASD children with and without the symptom of hyperactivity, which was evaluated using the Autism Diagnostic Observational Schedule, Generic (ADOS-G) subscale. However, there was a significant correlation between the degrees of hemispheric synchronization and the ability to keep still during 12-minute MEG recording periods. Our results also suggested that asynchrony in the bilateral brain auditory processing system is associated with ADHD-like symptoms in children with ASD.
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U2 - 10.1016/j.nicl.2016.07.009
DO - 10.1016/j.nicl.2016.07.009
M3 - Article
C2 - 27551667
AN - SCOPUS:84982931602
SN - 2213-1582
VL - 12
SP - 300
EP - 305
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -