Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−Mutyh−/− mice were more active and less anxious, with impaired learning ability. In contrast, Mutyh−/− mice showed moderately improved memory. We observed no apparent change in genomic 8-oxoG levels, suggesting that Ogg1 and Mutyh play minor roles in global repair in adult brain. Notably, transcriptome analysis of hippocampus revealed that differentially expressed genes in the mutants belong to pathways known to be involved in anxiety and cognition. Esr1 targets were upregulated, suggesting a role of Ogg1 and Mutyh in repression of Esr1 signaling. Thus, beyond their involvement in DNA repair, Ogg1 and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior. Ogg1 and Mutyh cooperate to prevent mutations caused by 8-oxoG. Bjørge et al. report increased activity, decreased anxiety, and impaired learning in Ogg1−/−Mutyh−/− mice but unaltered 8-oxoG levels. Genes involved in anxiety and cognition are differentially expressed in Ogg1−/−Mutyh−/− mice, suggesting Ogg1 and Mutyh modulate gene expression related to adaptive behavior.

Original languageEnglish
Pages (from-to)2671-2678
Number of pages8
JournalCell Reports
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 29 2015

Fingerprint

DNA Glycosylases
Gene expression
Repair
Anxiety
Genes
Cognition
DNA
Psychological Adaptation
Brain
Data storage equipment
Learning
Gene Expression
Mutation
Aptitude
Gene Expression Profiling
DNA Repair
Hippocampus

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bjørge, M. D., Hildrestrand, G. A., Scheffler, K., Suganthan, R., Rolseth, V., Kuśnierczyk, A., ... Bjørås, M. (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell Reports, 13(12), 2671-2678. https://doi.org/10.1016/j.celrep.2015.12.001

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. / Bjørge, Monica D.; Hildrestrand, Gunn A.; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy; Kuśnierczyk, Anna; Rowe, Alexander D.; Vågbø, Cathrine B.; Vetlesen, Susanne; Eide, Lars; Slupphaug, Geir; Nakabeppu, Yusaku; Bredy, Timothy W.; Klungland, Arne; Bjørås, Magnar.

In: Cell Reports, Vol. 13, No. 12, 29.12.2015, p. 2671-2678.

Research output: Contribution to journalArticle

Bjørge, MD, Hildrestrand, GA, Scheffler, K, Suganthan, R, Rolseth, V, Kuśnierczyk, A, Rowe, AD, Vågbø, CB, Vetlesen, S, Eide, L, Slupphaug, G, Nakabeppu, Y, Bredy, TW, Klungland, A & Bjørås, M 2015, 'Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice', Cell Reports, vol. 13, no. 12, pp. 2671-2678. https://doi.org/10.1016/j.celrep.2015.12.001
Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A et al. Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell Reports. 2015 Dec 29;13(12):2671-2678. https://doi.org/10.1016/j.celrep.2015.12.001
Bjørge, Monica D. ; Hildrestrand, Gunn A. ; Scheffler, Katja ; Suganthan, Rajikala ; Rolseth, Veslemøy ; Kuśnierczyk, Anna ; Rowe, Alexander D. ; Vågbø, Cathrine B. ; Vetlesen, Susanne ; Eide, Lars ; Slupphaug, Geir ; Nakabeppu, Yusaku ; Bredy, Timothy W. ; Klungland, Arne ; Bjørås, Magnar. / Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. In: Cell Reports. 2015 ; Vol. 13, No. 12. pp. 2671-2678.
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