Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

Kinichi Nakashima; Makoto Yanagisawa; Hirokazu Arakawa; Naoki Kimura; Tatsuhiro Hisatsune; Masahiro Kawabata; Kohei Miyazono; Tetsuya Taga

doi:10.1126/science.284.5413.479

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

Kinichi Nakashima, Makoto Yanagisawa, Hirokazu Arakawa, Naoki Kimura, Tatsuhiro Hisatsune, Masahiro Kawabata, Kohei Miyazono, Tetsuya Taga

Research output: Contribution to journal › Article › peer-review

375 Citations (Scopus)

Abstract

The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators of transcription) and Smads. LIF and BMP2 were found to act in synergy on primary fetal neural progenitor cells to induce astrocytes. The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner. The formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	Science
Volume	284
Issue number	5413
DOIs	https://doi.org/10.1126/science.284.5413.479
Publication status	Published - Apr 16 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

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abstract = "The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators of transcription) and Smads. LIF and BMP2 were found to act in synergy on primary fetal neural progenitor cells to induce astrocytes. The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner. The formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors.",

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T1 - Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

AU - Nakashima, Kinichi

AU - Yanagisawa, Makoto

AU - Arakawa, Hirokazu

AU - Kimura, Naoki

AU - Hisatsune, Tatsuhiro

AU - Kawabata, Masahiro

AU - Miyazono, Kohei

AU - Taga, Tetsuya

PY - 1999/4/16

Y1 - 1999/4/16

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AB - The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators of transcription) and Smads. LIF and BMP2 were found to act in synergy on primary fetal neural progenitor cells to induce astrocytes. The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner. The formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors.

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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

Abstract

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