Syntheses, antitumor activity, and molecular mechanics studies of cis-PtCl2(pzH)2 (pzH = pyrazole) and related complexes. Crystal structure of a novel Magnus-type double-salt [Pt(pzH)4][PtCl4][cis-PtCl2(pzH)2]2 involving two perpendicularly aligned 1D chains

Ken Sakai, Yasushi Tomita, Takuma Ue, Koji Goshima, Masakatsu Ohminato, Taro Tsubomura, Kazuko Matsumoto, Kenji Ohmura, Kazuyuki Kawakami

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Abstract

A new Magnus-type double-salt cocrystallized with a neutral complex, [Pt(pzH)4][PtCl4][cis-PtCl2(pzH)2]2 (1), has been isolated from a reaction between K2PtCl4 and pyrazole as a result of our reinvestigation of cis-PtCl2(pzH)2 (2). Interestingly, compound 1 involves two types of 1D chains respectively growing along the a- and c-axes, giving a novel intersecting framework. The former is {cis-PtCl2(pzH)2}(n) (Pt-Pt = 4.342(2) and 4.373(2) Å), and the latter is a Magnus-type 1D chain {[Pt(pzH)4][PtCl4]}(n) (Pt-Pt = 3.9388(1) Å). Each stacking interaction is stabilized with two hydrogen bonds formed between the chloride atoms and the N-H units of pyrazoles; Cl···N(pyrazole) = 3.21(2)-3.49(2) Å. The in vitro antitumor activity of 2 toward some human cancer cell lines is found to be comparable to that of cis-PtCl2(NH3)2. Molecular mechanics investigations of some GG-adducts of cis-Pt(pzH)2 reveal the importance of hydrogen-bond formation between the NH(pzH) units and the guanine/phosphate groups for the electrostatic stabilization of the adducts. (C) 2000 Elsevier Science S.A.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalInorganica Chimica Acta
Volume297
Issue number1-2
DOIs
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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