Syntheses, antitumor activity, and molecular mechanics studies of cis-PtCl2(pzH)2 (pzH = pyrazole) and related complexes. Crystal structure of a novel Magnus-type double-salt [Pt(pzH)4][PtCl4][cis-PtCl2(pzH)2]2 involving two perpendicularly aligned 1D chains

Ken Sakai, Yasushi Tomita, Takuma Ue, Koji Goshima, Masakatsu Ohminato, Taro Tsubomura, Kazuko Matsumoto, Kenji Ohmura, Kazuyuki Kawakami

Research output: Contribution to journalArticle

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Abstract

A new Magnus-type double-salt cocrystallized with a neutral complex, [Pt(pzH)4][PtCl4][cis-PtCl2(pzH)2]2 (1), has been isolated from a reaction between K2PtCl4 and pyrazole as a result of our reinvestigation of cis-PtCl2(pzH)2 (2). Interestingly, compound 1 involves two types of 1D chains respectively growing along the a- and c-axes, giving a novel intersecting framework. The former is {cis-PtCl2(pzH)2}(n) (Pt-Pt = 4.342(2) and 4.373(2) Å), and the latter is a Magnus-type 1D chain {[Pt(pzH)4][PtCl4]}(n) (Pt-Pt = 3.9388(1) Å). Each stacking interaction is stabilized with two hydrogen bonds formed between the chloride atoms and the N-H units of pyrazoles; Cl···N(pyrazole) = 3.21(2)-3.49(2) Å. The in vitro antitumor activity of 2 toward some human cancer cell lines is found to be comparable to that of cis-PtCl2(NH3)2. Molecular mechanics investigations of some GG-adducts of cis-Pt(pzH)2 reveal the importance of hydrogen-bond formation between the NH(pzH) units and the guanine/phosphate groups for the electrostatic stabilization of the adducts. (C) 2000 Elsevier Science S.A.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalInorganica Chimica Acta
Volume297
Issue number1-2
DOIs
Publication statusPublished - Oct 14 2000
Externally publishedYes

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Molecular mechanics
adducts
Hydrogen bonds
Salts
Crystal structure
Pyrazoles
hydrogen bonds
salts
crystal structure
guanines
Guanine
synthesis
cultured cells
Chlorides
Electrostatics
phosphates
Phosphates
Stabilization
stabilization
cancer

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Syntheses, antitumor activity, and molecular mechanics studies of cis-PtCl2(pzH)2 (pzH = pyrazole) and related complexes. Crystal structure of a novel Magnus-type double-salt [Pt(pzH)4][PtCl4][cis-PtCl2(pzH)2]2 involving two perpendicularly aligned 1D chains. / Sakai, Ken; Tomita, Yasushi; Ue, Takuma; Goshima, Koji; Ohminato, Masakatsu; Tsubomura, Taro; Matsumoto, Kazuko; Ohmura, Kenji; Kawakami, Kazuyuki.

In: Inorganica Chimica Acta, Vol. 297, No. 1-2, 14.10.2000, p. 64-71.

Research output: Contribution to journalArticle

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AU - Sakai, Ken

AU - Tomita, Yasushi

AU - Ue, Takuma

AU - Goshima, Koji

AU - Ohminato, Masakatsu

AU - Tsubomura, Taro

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