Syntheses, crystal structures, and single small molecule encapsulation properties of cavitand-porphyrins

Jun Nakazawa, Maki Mizuki, Jun Hagiwara, Yuichi Shimazaki, Fumito Tani, Yoshinori Naruta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

New capsule-shaped hosts "cavitand-linked porphyrin" metal complexes (Mcp: M =H 2, Ni, Zn, and Pd) have been synthesized to mimic the substrate binding functions of metalloenzymes such as cytochrome P-450 cam. Crystal structures of cavitand 1·MeOH·CHCl 3, [Zntpp(MeOH)], [Nicp]·MeOH·2CHCl 3· 3H 2O, [Zncp(MeOH)]·2CHCl 3·3H 2O, and [Pdcp]·MeOH·2CHCl 3·3H 2O have been determined. One methanol molecule, originating from crystallization solvent is encapsulated in each host cavity, and coordinates to Zn in Zncp but not in Ni- and Pdcp. Encapsulation of various small hydrocarbon molecules in CDCl 3 solutions of Mcps have been evaluated by determining binding constants and thermodynamic parameters obtained from 1HNMR titrations. All Mcps encapsulate hydrocarbons smaller than propane under atmospheric pressure. The guest size selectivity is primarily influenced by cavity size, and partly by metal insertion. The metal ion radius does not affect guest size selectivity. Encapsulation of coordinating guest molecules (MeOH, EtOH, MeCN, and H 2O) in Mcps has also been investigated. Only Zncp favors coordination of non-hydrocarbon guests such as MeOH. We concluded that accommodation of different size guests by Mcps depends upon guest sizes and coordination of functional groups depends upon both the identity of the porphyrin's metal ion and guest sizes.

Original languageEnglish
Pages (from-to)1431-1443
Number of pages13
JournalBulletin of the Chemical Society of Japan
Volume79
Issue number9
DOIs
Publication statusPublished - Nov 9 2006

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Porphyrins
Encapsulation
Crystal structure
Hydrocarbons
Molecules
Metal ions
Camphor 5-Monooxygenase
Propane
Coordination Complexes
Crystallization
Titration
Functional groups
Atmospheric pressure
Capsules
Methanol
Metals
Thermodynamics
Substrates
cavitand

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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Syntheses, crystal structures, and single small molecule encapsulation properties of cavitand-porphyrins. / Nakazawa, Jun; Mizuki, Maki; Hagiwara, Jun; Shimazaki, Yuichi; Tani, Fumito; Naruta, Yoshinori.

In: Bulletin of the Chemical Society of Japan, Vol. 79, No. 9, 09.11.2006, p. 1431-1443.

Research output: Contribution to journalArticle

Nakazawa, Jun ; Mizuki, Maki ; Hagiwara, Jun ; Shimazaki, Yuichi ; Tani, Fumito ; Naruta, Yoshinori. / Syntheses, crystal structures, and single small molecule encapsulation properties of cavitand-porphyrins. In: Bulletin of the Chemical Society of Japan. 2006 ; Vol. 79, No. 9. pp. 1431-1443.
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