Syntheses of all poasible calix[6]arene derivatives with MeO- and ROCOCH₂O- substituents and their metal binding properties

It has become possible to synthesize all possible calix[6]arene derivatives with MeO-and ROCOCH₂O- substituents from corresponding O-methylated calix[6]arenes(2-7). The yields of these reactions were relatively high and the products could be easily purified because of the absence of other regioisomers. They are one mono-, three di-, three tri-, three tetra-, one penta-, and one hexa-EtOCOCH₂O-substituted products. It was proved that O-methylation products act as useful basic skeletons to design functionalized calix[6]arenes with the desired number of ROCOCH₂O substituents and the regioselectively-positioned ROCOCH₂O groups.