Abstract
One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.
Original language | English |
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Pages (from-to) | 5197-5199 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 28 |
DOIs | |
Publication status | Published - Jul 7 2003 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry