Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi, Takeshi Kaieda, Takashi Matsuo, Hideaki Sato, Yoshio Hisaeda

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Abstract

One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

Original languageEnglish
Pages (from-to)5197-5199
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number28
DOIs
Publication statusPublished - Jul 7 2003

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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