Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi; Takeshi Kaieda; Takashi Matsuo; Hideaki Sato; Yoshio Hisaeda

doi:10.1016/S0040-4039(03)01252-8

Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi, Takeshi Kaieda, Takashi Matsuo, Hideaki Sato, Yoshio Hisaeda

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33 Citations (Scopus)

Abstract

One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by ¹H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

Original language	English
Pages (from-to)	5197-5199
Number of pages	3
Journal	Tetrahedron Letters
Volume	44
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4039(03)01252-8
Publication status	Published - Jul 7 2003

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(03)01252-8

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title = "Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage",

abstract = "One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.",

author = "Hisashi Shimakoshi and Takeshi Kaieda and Takashi Matsuo and Hideaki Sato and Yoshio Hisaeda",

note = "Funding Information: We thank Professor T. Hayashi (Kyushu University) for useful discussions and Professor S. Takenaka and Dr. K. Yamashita (Kyushu University) for help with gel-electrophoretic analyses. This work was partially supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

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doi = "10.1016/S0040-4039(03)01252-8",

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T1 - Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

AU - Shimakoshi, Hisashi

AU - Kaieda, Takeshi

AU - Matsuo, Takashi

AU - Sato, Hideaki

AU - Hisaeda, Yoshio

N1 - Funding Information: We thank Professor T. Hayashi (Kyushu University) for useful discussions and Professor S. Takenaka and Dr. K. Yamashita (Kyushu University) for help with gel-electrophoretic analyses. This work was partially supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2003/7/7

Y1 - 2003/7/7

N2 - One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

AB - One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

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U2 - 10.1016/S0040-4039(03)01252-8

DO - 10.1016/S0040-4039(03)01252-8

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

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Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

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