Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi; Takeshi Kaieda; Takashi Matsuo; Hideaki Sato; Yoshio Hisaeda

doi:10.1016/S0040-4039(03)01252-8

Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi, Takeshi Kaieda, Takashi Matsuo, Hideaki Sato, Yoshio Hisaeda

Biofunctional Chemistry

Research output: Contribution to journal › Article

31 Citations (Scopus)

Abstract

One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by ¹H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

Original language	English
Pages (from-to)	5197-5199
Number of pages	3
Journal	Tetrahedron Letters
Volume	44
Issue number	28
DOIs	https://doi.org/10.1016/S0040-4039(03)01252-8
Publication status	Published - Jul 7 2003

Fingerprint

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Shimakoshi, H., Kaieda, T., Matsuo, T., Sato, H., & Hisaeda, Y. (2003). Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage. Tetrahedron Letters, 44(28), 5197-5199. https://doi.org/10.1016/S0040-4039(03)01252-8

@article{3ba7ca3dc1a047cb85b9be0cee3e9c6c,

title = "Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage",

abstract = "One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.",

author = "Hisashi Shimakoshi and Takeshi Kaieda and Takashi Matsuo and Hideaki Sato and Yoshio Hisaeda",

year = "2003",

month = "7",

day = "7",

doi = "10.1016/S0040-4039(03)01252-8",

language = "English",

volume = "44",

pages = "5197--5199",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "28",

}

TY - JOUR

T1 - Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

AU - Shimakoshi, Hisashi

AU - Kaieda, Takeshi

AU - Matsuo, Takashi

AU - Sato, Hideaki

AU - Hisaeda, Yoshio

PY - 2003/7/7

Y1 - 2003/7/7

N2 - One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

AB - One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

UR - http://www.scopus.com/inward/record.url?scp=0038684458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038684458&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(03)01252-8

DO - 10.1016/S0040-4039(03)01252-8

M3 - Article

AN - SCOPUS:0038684458

VL - 44

SP - 5197

EP - 5199

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 28

ER -

Access to Document

10.1016/S0040-4039(03)01252-8