Synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against T98G brain cancer cells

Nagendra Kumar Kaushik, Pankaj Attri, Neha Kaushik, Eun Ha Choi

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28 Citations (Scopus)

Abstract

Four ammonium and imidazolium ionic liquids (ILs) have been synthesized and screened against the T98G cell line (brain cancer) and HEK normal cells. Treatment induced metabolic cell death (MTT), growth inhibition, clonogenic inhibition were studied as cellular response parameters. Treatment with ILs enhanced growth inhibition and cell death in a concentration dependent manner in both the T98G and HEK cell lines. At higher concentrations (>0.09 mg/mL) the cytotoxic effects of the ILs were highly significant. An inhibitory effect on clonogenic capacity was also observed after cell treatment. Amongst all ILs IL 4 (BMIMCl) exhibited potent activity against T98G brain cancer cells. Despite potent in-vitro activity, all ILs exhibited less cytotoxicity against the normal human HEK cells at all effective concentrations.

Original languageEnglish
Pages (from-to)13727-13739
Number of pages13
JournalMolecules
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 1 2012
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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