Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core

Takaaki Fukui, Yoshiharu Otsuka, Keigo Aoi, Keiji Tanaka, Toshihiko Nagamura

Research output: Contribution to conferencePaperpeer-review

Abstract

We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Fingerprint Dive into the research topics of 'Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core'. Together they form a unique fingerprint.

Cite this