Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core

Takaaki Fukui, Yoshiharu Otsuka, Keigo Aoi, Keiji Tanaka, Toshihiko Nagamura

Research output: Contribution to conferencePaper

Abstract

We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

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Dendrimers
Polyethers
Sugars
Glycosylation
Liver
Polyethylene glycols
Disaccharides
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Fukui, T., Otsuka, Y., Aoi, K., Tanaka, K., & Nagamura, T. (2005). Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.

Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core. / Fukui, Takaaki; Otsuka, Yoshiharu; Aoi, Keigo; Tanaka, Keiji; Nagamura, Toshihiko.

2005. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.

Research output: Contribution to conferencePaper

Fukui, T, Otsuka, Y, Aoi, K, Tanaka, K & Nagamura, T 2005, 'Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core', Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan, 9/20/05 - 9/22/05.
Fukui T, Otsuka Y, Aoi K, Tanaka K, Nagamura T. Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core. 2005. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.
Fukui, Takaaki ; Otsuka, Yoshiharu ; Aoi, Keigo ; Tanaka, Keiji ; Nagamura, Toshihiko. / Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.1 p.
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