Synthesis and Binding Properties of Monomeric and Dimeric Guanine and Cytosine Amine Derivatives

Jonathan L. Sessler, Darren Magda, Hiroyuki Furuta

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The syntheses of the N-protected forms of the cytosine homodimer 1, the guanine cytosine heterodimer 2, and the guanine homodimer 3 are described. Derivatization of these dimers, as well as the protected monomers corresponding to 4 and 5, with ω-methoxypoly(ethylene glycol)-α-carboxylic acid 26 and subsequent deprotection formed the amides 29, 31, 33, 35, and 37. The binding properties of these solubilized compounds in DMSO-d6 were examined using 1H NMR.

Original languageEnglish
Pages (from-to)818-826
Number of pages9
JournalJournal of Organic Chemistry
Issue number3
Publication statusPublished - Jan 1 1992
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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