Synthesis and bio-applications of carbohydrate-gold nanoconjugates with nanoparticle and nanolayer forms

Takuya Kitaoka, Shingo Yokota, Martina Opietnik, Thomas Rosenau

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Carbohydrate-conjugated gold nanoparticles (GNPs) and gold nanolayers (GNLs), which have recently attracted increasing attention as innovative nano-biomaterials, were successfully synthesized using carbohydrate thiosemicarbazones in an aqueous N-methylmorpholine N-oxide (NMMO) system. This system can dissolve various types of carbohydrates including structural polysaccharides, e.g., cellulose. We observed that oxidative NMMO solvent unexpectedly promoted the immediate reduction of [AuIIICl 4]- species to nanosized metallic Au0, that is GNP. One possible mechanism is that the chloride ligand was oxidized to chlorate via the formation of a hypochlorite intermediate. Site-selective S-labeling of sugar reducing ends with thiosemicarbazide may have enabled regulated self-assembly immobilization to the surfaces of GNPs and GNLs. The carbohydrate-gold nanoconjugates possess unique nanoarchitectures and biofunctions for carbohydrate-cell interactions. Novel and simple approaches for the structural design of carbohydrate-decorated GNPs and GNLs in the NMMO system have potential to inspire a new phase in glyco-biomaterials engineering.

Original languageEnglish
Pages (from-to)1221-1229
Number of pages9
JournalMaterials Science and Engineering C
Volume31
Issue number6
DOIs
Publication statusPublished - Aug 12 2011

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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