Synthesis and biological activity of selective azasugar-based TACE inhibitors

Takahiro Tsukida, Hideki Moriyama, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin Ichiro Nishimura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.

Original languageEnglish
Pages (from-to)1569-1572
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number6
DOIs
Publication statusPublished - Mar 22 2004
Externally publishedYes

Fingerprint

Bioactivity
Matrix Metalloproteinases
Bearings (structural)
Hydroxamic Acids
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and biological activity of selective azasugar-based TACE inhibitors. / Tsukida, Takahiro; Moriyama, Hideki; Inoue, Yoshimasa; Kondo, Hirosato; Yoshino, Kohichiro; Nishimura, Shin Ichiro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 6, 22.03.2004, p. 1569-1572.

Research output: Contribution to journalArticle

Tsukida, Takahiro ; Moriyama, Hideki ; Inoue, Yoshimasa ; Kondo, Hirosato ; Yoshino, Kohichiro ; Nishimura, Shin Ichiro. / Synthesis and biological activity of selective azasugar-based TACE inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 6. pp. 1569-1572.
@article{f74dfdb2401e48c1b23a96e08288118d,
title = "Synthesis and biological activity of selective azasugar-based TACE inhibitors",
abstract = "A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.",
author = "Takahiro Tsukida and Hideki Moriyama and Yoshimasa Inoue and Hirosato Kondo and Kohichiro Yoshino and Nishimura, {Shin Ichiro}",
year = "2004",
month = "3",
day = "22",
doi = "10.1016/j.bmcl.2003.12.091",
language = "English",
volume = "14",
pages = "1569--1572",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Synthesis and biological activity of selective azasugar-based TACE inhibitors

AU - Tsukida, Takahiro

AU - Moriyama, Hideki

AU - Inoue, Yoshimasa

AU - Kondo, Hirosato

AU - Yoshino, Kohichiro

AU - Nishimura, Shin Ichiro

PY - 2004/3/22

Y1 - 2004/3/22

N2 - A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.

AB - A series of azasugar-based hydroxamic acid derivatives bearing 2R,3R,4R,5R-configuration is described. Compound 4c with 4,5-O-acetonide group showed excellent in vitro potency against TACE, with high selectivity over MMP-1 and moderate selectivity over MMP-3 and MMP-9.

UR - http://www.scopus.com/inward/record.url?scp=1542314917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542314917&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2003.12.091

DO - 10.1016/j.bmcl.2003.12.091

M3 - Article

C2 - 15006405

AN - SCOPUS:1542314917

VL - 14

SP - 1569

EP - 1572

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 6

ER -