Synthesis and characterization of polysaccharide-oligonucleotide conjugate

Naoya Fukuda, Naohiko Shimada, Seiji Shinkai, Kazuo Sakurai

Research output: Contribution to conferencePaper

Abstract

We have reported that SPG can from a complex with oligodeoxynucleotide (ODN) attaching (<A20) tail at 3′ end. However, SPG cannot form the complex with ODN attaching short tail (<dAso) due to reduction of thermodynamic stability. In this study, we examined whether ODN-conjugated SPG can form an intramolecular complex. dA20 was introduced to reducing terminal of SPG via diaminoalkanes or diaminoPEGs. The conjugates were purified by gel-filtration. CD spectrum of the conjugate indicated a formation of intramolecular complex.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Fukuda, N., Shimada, N., Shinkai, S., & Sakurai, K. (2006). Synthesis and characterization of polysaccharide-oligonucleotide conjugate. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.