Synthesis and in vitro behavior of organically modified silicate containing Ca ions

Kanji Tsuru, Yasushi Aburatani, Takeshi Yabuta, Satoshi Hayakawa, Chikara Ohtsuki, Akiyoshi Osaka

Research output: Contribution to journalArticle

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Abstract

Organically modified silicates containing calcium ion have a potential to bond to bone via an apatite layer deposited on their surfaces in the body environment. In this study, we examined the relationship between apatite deposition and the microstructure of the organically modified silicates synthesized from tetraethoxysilane (TEOS) and poly (dimethylsiloxane) (PDMS) with a different amount of calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) hydrochloric acid (HCl). Apatite deposition was evaluated in vitro using a simulated body fluid (Kokubo solution). Copolymerization was confirmed between TEOS and PDMS even if PDMS free from-SiOH termination are used as one of the starting materials. The porosity and Ca content incorporated in the structure depended on the amount of HCl, whereas analysis of 29Si MAS NMR spectra indicates that it caused few effects on the local structure around Si atoms. Apatite-forming ability is enhanced by optimal amounts of HCl and Ca (NO3)2·4H2O. The difference apatite-forming ability among the hybrid gels was attributed to both Ca(II) contents in the structure and aggregation states of the Si-OH groups. Better bioactivity of the hybrid gels is achieved by the release of Ca(II) ions trapped in structure at gelation and the formation of hydrated silica rich in Si-OH.

Original languageEnglish
Article number333558
Pages (from-to)89-96
Number of pages8
JournalJournal of Sol-Gel Science and Technology
Volume21
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2001

Fingerprint

Silicates
Apatites
Apatite
apatites
silicates
Ions
Hydrochloric Acid
hydrochloric acid
Polydimethylsiloxane
Hydrochloric acid
synthesis
ions
Calcium
Gels
Trapped ions
gels
calcium silicates
body fluids
Body fluids
gelation

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Biomaterials
  • Condensed Matter Physics
  • Materials Chemistry

Cite this

Tsuru, K., Aburatani, Y., Yabuta, T., Hayakawa, S., Ohtsuki, C., & Osaka, A. (2001). Synthesis and in vitro behavior of organically modified silicate containing Ca ions. Journal of Sol-Gel Science and Technology, 21(1-2), 89-96. [333558]. https://doi.org/10.1023/A:1011217818285

Synthesis and in vitro behavior of organically modified silicate containing Ca ions. / Tsuru, Kanji; Aburatani, Yasushi; Yabuta, Takeshi; Hayakawa, Satoshi; Ohtsuki, Chikara; Osaka, Akiyoshi.

In: Journal of Sol-Gel Science and Technology, Vol. 21, No. 1-2, 333558, 01.01.2001, p. 89-96.

Research output: Contribution to journalArticle

Tsuru, K, Aburatani, Y, Yabuta, T, Hayakawa, S, Ohtsuki, C & Osaka, A 2001, 'Synthesis and in vitro behavior of organically modified silicate containing Ca ions', Journal of Sol-Gel Science and Technology, vol. 21, no. 1-2, 333558, pp. 89-96. https://doi.org/10.1023/A:1011217818285
Tsuru, Kanji ; Aburatani, Yasushi ; Yabuta, Takeshi ; Hayakawa, Satoshi ; Ohtsuki, Chikara ; Osaka, Akiyoshi. / Synthesis and in vitro behavior of organically modified silicate containing Ca ions. In: Journal of Sol-Gel Science and Technology. 2001 ; Vol. 21, No. 1-2. pp. 89-96.
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