Four optically active isomers (optical purity >94.6% d.e.) of 2-methoxy-5-phenyl-l, 3, 2- oxazaphospholidine 2-sulfide (5-PMOS) were synthesized by a two-step phosphorylating method, and their insecticidal activities were determined against susceptible (SRS) and resistant (3-YF) strains of house flies by topical application. The relationship between the configuration and insecticidal activity was similar in the susceptible and resistant strains of house flies. The (R)C(R)P-isomer showed the highest insecticidal activity, followed by (R)C(S)P>(S)C(R)P>(S)C(S)P.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)