Synthesis and insecticidal activity of optically active 2-methoxy- 5-phenyl-1, 3, 2-oxazaphospholidine 2-sulfide

Shao Yong Wu, Akinori Hirashima, Ryuko Takeya, Morifusa Eto

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Four optically active isomers (optical purity >94.6% d.e.) of 2-methoxy-5-phenyl-l, 3, 2- oxazaphospholidine 2-sulfide (5-PMOS) were synthesized by a two-step phosphorylating method, and their insecticidal activities were determined against susceptible (SRS) and resistant (3-YF) strains of house flies by topical application. The relationship between the configuration and insecticidal activity was similar in the susceptible and resistant strains of house flies. The (R)C(R)P-isomer showed the highest insecticidal activity, followed by (R)C(S)P>(S)C(R)P>(S)C(S)P.

Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalAgricultural and Biological Chemistry
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 1989

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Musca domestica
Sulfides
sulfides
Diptera
Isomers
isomers
synthesis
topical application
purity
(1,3,2)oxazaphospholidine
methodology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Synthesis and insecticidal activity of optically active 2-methoxy- 5-phenyl-1, 3, 2-oxazaphospholidine 2-sulfide. / Wu, Shao Yong; Hirashima, Akinori; Takeya, Ryuko; Eto, Morifusa.

In: Agricultural and Biological Chemistry, Vol. 53, No. 1, 01.01.1989, p. 165-174.

Research output: Contribution to journalArticle

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