Synthesis and properties of N-t-butylaminoxyl nucleosides.

Toshiyuki Kaneko, Mariko Aso, Morihide Nakamura, Yasuhiro Matsui, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticle

Abstract

Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.

Original languageEnglish
Pages (from-to)139-140
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
Publication statusPublished - Jan 1 2002

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Purine Nucleosides
Uridine
Nucleosides
Oligonucleotides
Spectrum Analysis
Air
DNA
purine

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kaneko, T., Aso, M., Nakamura, M., Matsui, Y., Koga, N., & Suemune, H. (2002). Synthesis and properties of N-t-butylaminoxyl nucleosides. Nucleic acids research. Supplement (2001), (2), 139-140.

Synthesis and properties of N-t-butylaminoxyl nucleosides. / Kaneko, Toshiyuki; Aso, Mariko; Nakamura, Morihide; Matsui, Yasuhiro; Koga, Noboru; Suemune, Hiroshi.

In: Nucleic acids research. Supplement (2001), No. 2, 01.01.2002, p. 139-140.

Research output: Contribution to journalArticle

Kaneko, T, Aso, M, Nakamura, M, Matsui, Y, Koga, N & Suemune, H 2002, 'Synthesis and properties of N-t-butylaminoxyl nucleosides.', Nucleic acids research. Supplement (2001), no. 2, pp. 139-140.
Kaneko T, Aso M, Nakamura M, Matsui Y, Koga N, Suemune H. Synthesis and properties of N-t-butylaminoxyl nucleosides. Nucleic acids research. Supplement (2001). 2002 Jan 1;(2):139-140.
Kaneko, Toshiyuki ; Aso, Mariko ; Nakamura, Morihide ; Matsui, Yasuhiro ; Koga, Noboru ; Suemune, Hiroshi. / Synthesis and properties of N-t-butylaminoxyl nucleosides. In: Nucleic acids research. Supplement (2001). 2002 ; No. 2. pp. 139-140.
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