Abstract
Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.
Original language | English |
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Pages (from-to) | 139-140 |
Number of pages | 2 |
Journal | Nucleic acids research. Supplement (2001) |
Issue number | 2 |
Publication status | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Synthesis and properties of N-t-butylaminoxyl nucleosides. / Kaneko, Toshiyuki; Aso, Mariko; Nakamura, Morihide; Matsui, Yasuhiro; Koga, Noboru; Suemune, Hiroshi.
In: Nucleic acids research. Supplement (2001), No. 2, 01.01.2002, p. 139-140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and properties of N-t-butylaminoxyl nucleosides.
AU - Kaneko, Toshiyuki
AU - Aso, Mariko
AU - Nakamura, Morihide
AU - Matsui, Yasuhiro
AU - Koga, Noboru
AU - Suemune, Hiroshi
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.
AB - Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.
UR - http://www.scopus.com/inward/record.url?scp=0041818074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041818074&partnerID=8YFLogxK
M3 - Article
C2 - 12903144
AN - SCOPUS:0041818074
SP - 139
EP - 140
JO - Nucleic acids research. Supplement (2001)
JF - Nucleic acids research. Supplement (2001)
IS - 2
ER -