Synthesis and properties of N-t-butylaminoxyl nucleosides.

Toshiyuki Kaneko; Mariko Aso; Morihide Nakamura; Yasuhiro Matsui; Noboru Koga; Hiroshi Suemune

doi:10.1093/nass/2.1.139

Synthesis and properties of N-t-butylaminoxyl nucleosides.

Toshiyuki Kaneko, Mariko Aso, Morihide Nakamura, Yasuhiro Matsui, Noboru Koga, Hiroshi Suemune

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.

Original language	English
Pages (from-to)	139-140
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	2
DOIs	https://doi.org/10.1093/nass/2.1.139
Publication status	Published - 2002

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abstract = "Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.",

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AU - Nakamura, Morihide

AU - Matsui, Yasuhiro

AU - Koga, Noboru

AU - Suemune, Hiroshi

PY - 2002

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