Synthesis and properties of N-t-butylaminoxyl nucleosides.

Toshiyuki Kaneko, Mariko Aso, Morihide Nakamura, Yasuhiro Matsui, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticlepeer-review

Abstract

Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.

Original languageEnglish
Pages (from-to)139-140
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
DOIs
Publication statusPublished - 2002

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