Synthesis and reactions of 1-methyl-5-tributylstannyl-4-trifluoromethylpyrazole

Takeshi Hanamoto, Mikio Egashira, Kentaro Ishizuka, Hiroshi Furuno, Junji Inanaga

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


N-Methylation at the pyrazole ring by sequential treatment of 5-tributylstannyl-4-trifluoromethylpyrazole with LDA and iodomethane regioselectively provided the title compound in high yield. The addition reaction of 5-lithiated-4-trifluoromethylpyrazole with a wide range of electrophiles allowed easy and high-yielding introduction of substituents on position 5.

Original languageEnglish
Pages (from-to)6332-6338
Number of pages7
Issue number26
Publication statusPublished - Jun 26 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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