Synthesis and relaxivities of oligonucleotides with TEMPO-labeled sugar moiety.

Manami Okazaki, Yuichiro Sato, Satoru Karasawa, Noboru Koga

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Abstract

5-Uridin derivative, UUT, having TEMPO radical at the 2'-position of sugar moiety, was prepared and characterized by X-ray crystallography. The single strands, ssUUT, incorporating UUT and the double strands, dsUUT, with complimentary strand were also obtained. Their EPR spectra and relaxivities (25 MHz and 0.59 T) in water were measured. The values of tau R obtained from the simulation of EPR spectra and the water-proton relaxivities, r1 and r2, increased in order of UUT, ssUUT, and dsUUT.

Original languageEnglish
Pages (from-to)375-376
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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