Abstract
C4-Methyl substituted nine-membered diallylic cyclic amide 1ac was synthesized. HPLC analysis using a chiral stationary phase revealed the presence of isolable enantiomers, whose absolute stereochemistry were determined by X-ray analysis. Studies on the stereochemical stability of 1ac showed that its chirality is more labile than that of the non-substituted congener 1aa and C3-methyl substituted congener 1ab.
Original language | English |
---|---|
Pages (from-to) | 856-864 |
Number of pages | 9 |
Journal | Heterocycles |
Volume | 99 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2019 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Pharmacology
- Organic Chemistry