Synthesis, Conformational Properties and DFT Computational Studies of Polymethyl-Substituted [3.3]Metacyclophanes

Md Monarul Islam, Thamina Akther, Shofiur Rahman, Paris E. Georghiou, Taisuke Matsumoto, Junji Tanaka, Carl Redshaw, Takehiko Yamato

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6 Citations (Scopus)

Abstract

Polymethyl substituted [3.3]metacyclophanes (MCPs) 4 a–d, were synthesized by the TosMIC coupling method followed by Wolff–Kishner reduction of the corresponding polymethyl-substituted [3.3]MCP-2,11-diones (3 a–d). 1H NMR spectroscopy reveals that both 5,6,7,14,16-pentamethyl[3.3]MCP-2,11-diones (3 a and 3 b) undergo conformational changes relative to the NMR time scale in solution at room temperature but that the anti conformer is preferred. Reduced 5,6,7,14,16-pentamethyl[3.3]MCP (4 a and 4 b) adopt fixed syn–conformations in solution at room temperature. X-ray analysis showed that in the solid state, 5,6,7,14,15,16-hexamethyl[3.3]MCP-2,11-dione 3 a adopts the anti-conformation and reduced 5,6,7,14,16-pentamethyl[3.3]MCP-2,11-diones 4 b adopts a syn-(chair-chair) conformation. A series of electrophilic substitution reactions such as formylation, acetylation and nitration were carried out with 5,6,7,14,16-pentamethyl[3.3]MCP 4 b to study their conformational isomers. The formyl, acetyl and nitro derivatives of 5,6,7,14,16-pentamethyl[3.3]MCP are fixed to adopt syn-conformations in solution at room temperature. The conformational isomers of the metacyclophanes and derivatives obtained from density functional theory (DFT) methods were used to estimate the total energies and energy minimized structures of the different conformations.

Original languageEnglish
Pages (from-to)7255-7262
Number of pages8
JournalChemistrySelect
Volume2
Issue number24
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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