Synthesis of α,α-dibromo esters as precursors of ynolates

Mitsuru Shindo; Yusuke Sato; Ryoko Koretsune; Takashi Yoshikawa; Kenji Matsumoto; Kotaro Itoh; Kozo Shishido

doi:10.1248/cpb.51.477

Synthesis of α,α-dibromo esters as precursors of ynolates

Mitsuru Shindo, Yusuke Sato, Ryoko Koretsune, Takashi Yoshikawa, Kenji Matsumoto, Kotaro Itoh, Kozo Shishido

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α, α-dibromo esters were synthesized via radical bromination.

Original language	English
Pages (from-to)	477-478
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	4
DOIs	https://doi.org/10.1248/cpb.51.477
Publication status	Published - Apr 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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abstract = "Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α, α-dibromo esters were synthesized via radical bromination.",

author = "Mitsuru Shindo and Yusuke Sato and Ryoko Koretsune and Takashi Yoshikawa and Kenji Matsumoto and Kotaro Itoh and Kozo Shishido",

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AU - Shindo, Mitsuru

AU - Sato, Yusuke

AU - Koretsune, Ryoko

AU - Yoshikawa, Takashi

AU - Matsumoto, Kenji

AU - Itoh, Kotaro

AU - Shishido, Kozo

PY - 2003/4

Y1 - 2003/4

N2 - Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α, α-dibromo esters were synthesized via radical bromination.

AB - Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α, α-dibromo esters were synthesized via radical bromination.

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JO - Chemical and Pharmaceutical Bulletin

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Synthesis of α,α-dibromo esters as precursors of ynolates

Abstract

All Science Journal Classification (ASJC) codes

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