Synthesis of α,α-dibromo esters as precursors of ynolates

Mitsuru Shindo, Yusuke Sato, Ryoko Koretsune, Takashi Yoshikawa, Kenji Matsumoto, Kotaro Itoh, Kozo Shishido

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α, α-dibromo esters were synthesized via radical bromination.

Original languageEnglish
Pages (from-to)477-478
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number4
DOIs
Publication statusPublished - Jan 1 2003
Externally publishedYes

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Esters
Halogenation
Lithium
1,2-dibromotetrafluoroethane

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Shindo, M., Sato, Y., Koretsune, R., Yoshikawa, T., Matsumoto, K., Itoh, K., & Shishido, K. (2003). Synthesis of α,α-dibromo esters as precursors of ynolates. Chemical and Pharmaceutical Bulletin, 51(4), 477-478. https://doi.org/10.1248/cpb.51.477

Synthesis of α,α-dibromo esters as precursors of ynolates. / Shindo, Mitsuru; Sato, Yusuke; Koretsune, Ryoko; Yoshikawa, Takashi; Matsumoto, Kenji; Itoh, Kotaro; Shishido, Kozo.

In: Chemical and Pharmaceutical Bulletin, Vol. 51, No. 4, 01.01.2003, p. 477-478.

Research output: Contribution to journalArticle

Shindo, M, Sato, Y, Koretsune, R, Yoshikawa, T, Matsumoto, K, Itoh, K & Shishido, K 2003, 'Synthesis of α,α-dibromo esters as precursors of ynolates', Chemical and Pharmaceutical Bulletin, vol. 51, no. 4, pp. 477-478. https://doi.org/10.1248/cpb.51.477
Shindo M, Sato Y, Koretsune R, Yoshikawa T, Matsumoto K, Itoh K et al. Synthesis of α,α-dibromo esters as precursors of ynolates. Chemical and Pharmaceutical Bulletin. 2003 Jan 1;51(4):477-478. https://doi.org/10.1248/cpb.51.477
Shindo, Mitsuru ; Sato, Yusuke ; Koretsune, Ryoko ; Yoshikawa, Takashi ; Matsumoto, Kenji ; Itoh, Kotaro ; Shishido, Kozo. / Synthesis of α,α-dibromo esters as precursors of ynolates. In: Chemical and Pharmaceutical Bulletin. 2003 ; Vol. 51, No. 4. pp. 477-478.
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