TY - JOUR
T1 - Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives
AU - Nagatsugi, Fumi
AU - Sasaki, Shigeki
AU - Maeda, Minoru
N1 - Funding Information:
Financial support for this work from the Ministry of Education, Science and Culture, Japan, and the Fqjisawa Foundation is gratefully acknowledged.
PY - 1992/3
Y1 - 1992/3
N2 - Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis. The synthetic procedures offer easy and convenient access to the corresponding 18F-labeled analogs using the readily available [18F]fluoride ion.
AB - Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis. The synthetic procedures offer easy and convenient access to the corresponding 18F-labeled analogs using the readily available [18F]fluoride ion.
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U2 - 10.1016/S0022-1139(00)81186-0
DO - 10.1016/S0022-1139(00)81186-0
M3 - Article
AN - SCOPUS:0007478131
SN - 0022-1139
VL - 56
SP - 373
EP - 383
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
IS - 3
ER -