Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp3 C–H bonds

Kazuhiro Morisaki, Yuta Kondo, Masanao Sawa, Hiroyuki Morimoto, Takashi Ohshima

Research output: Contribution to journalArticlepeer-review

Abstract

This note describes the construction of tetrasubstituted carbon stereocenters via palladium-catalyzed allylation of sp3 C–H bonds of 2,2,2-trifluoroethylamine derivatives. The presence of 2-pyridyl group of the imines derived from 1-substituted-2,2,2-trifluoroethylamine was key to promoting the reaction efficiently, allowing an access to a variety of 1-allylated 2,2,2-trifluoroethylamine derivatives with tetrasubstituted carbon stereocenters.

Original languageEnglish
Pages (from-to)1089-1092
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume65
Issue number11
DOIs
Publication statusPublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp<sup>3</sup> C–H bonds'. Together they form a unique fingerprint.

Cite this