Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp3 C–H bonds

Kazuhiro Morisaki, Yuta Kondo, Masanao Sawa, Hiroyuki Morimoto, Takashi Ohshima

Research output: Contribution to journalArticle

Abstract

This note describes the construction of tetrasubstituted carbon stereocenters via palladium-catalyzed allylation of sp3 C–H bonds of 2,2,2-trifluoroethylamine derivatives. The presence of 2-pyridyl group of the imines derived from 1-substituted-2,2,2-trifluoroethylamine was key to promoting the reaction efficiently, allowing an access to a variety of 1-allylated 2,2,2-trifluoroethylamine derivatives with tetrasubstituted carbon stereocenters.

Original languageEnglish
Pages (from-to)1089-1092
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume65
Issue number11
DOIs
Publication statusPublished - Jan 1 2017

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Allylation
Palladium
Derivatives
Carbon
Imines
trifluoroethylamine

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp3 C–H bonds. / Morisaki, Kazuhiro; Kondo, Yuta; Sawa, Masanao; Morimoto, Hiroyuki; Ohshima, Takashi.

In: Chemical and Pharmaceutical Bulletin, Vol. 65, No. 11, 01.01.2017, p. 1089-1092.

Research output: Contribution to journalArticle

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