Synthesis of 2-substituted myo-inositol 1,3,4,5-tetrakis(phosphate) and 1,3,4,5,6-pentakis(phosphate) analogs

S. Ozaki, Y. Koga, L. Ling, Y. Watanabe, Y. Kimura, M. Hirata

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Some biologically interesting inositol poly(phosphate) derivatives, 2-O-(P-aminobenzoyl)-myo-inositol 1,3,4,5-tetrakis(phosphate), 2-O-(4-aminocyclohexylcarbonyl)-myo-inositol 1,3,4,5-tetrakis(phosphate), myo-inositol 1,3,4,5,6-pentakis(phosphate), and its 2-substituted analogs, were synthesized. Inositol tetrakis(phosphate) and pentakis(phosphate) affinity columns were also prepared. The inositol 1,3,4,5-tetrakis(phosphate) affinity column was found to be effective in isolating the binding proteins from bovine cardiac membranes.

Original languageEnglish
Pages (from-to)1058-1063
Number of pages6
JournalBulletin of the Chemical Society of Japan
Volume67
Issue number4
DOIs
Publication statusPublished - Jun 29 1994

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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