Synthesis of 20‐[18F]fluoroarachidonic acid: A potential phospholipid metabolic agent

Fumi Nagatsugi, Junji Hokazono, Shigeki Sasaki, Minoru Maeda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A fluorine‐18 labelled analog of arachidonic acid, 20‐[18F]fluoroarachidonic acid, was prepared for evaluation as a potential phospholipid metabolic agent. The radiosynthesis was accomplished by [18F]fluoride ion displacement on the tosylate precursor followed by basic hydrolysis of the ester group, in isolated radiochemical yield (not decay corrected) of 10 % in overall synthesis time (including HPLC purification) of 110 min.

Original languageEnglish
Pages (from-to)1121-1127
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume34
Issue number12
DOIs
Publication statusPublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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