Synthesis of 25- 13c-amphotericin B methyl ester: A molecular probe for solid-state NMR measurements

Naohiro Matsushita; Yukiko Matsuo; Hiroshi Tsuchikawa; Nobuaki Matsumori; Michio Murata; Tohru Oishi

doi:10.1246/cl.2009.114

Synthesis of 25- ¹³c-amphotericin B methyl ester: A molecular probe for solid-state NMR measurements

Naohiro Matsushita, Yukiko Matsuo, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata, Tohru Oishi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A ¹³C-labeled amphotericin B (AmB) derivative was synthesized based on a hybrid strategy combining chemical synthesis with degradation of a natural product through successive cross-coupling reactions and macrolactonization. The specimen regiospecifically ¹³C-labeled (99% enrichment) at C25 position corresponding to the polyene moiety would be a powerful tool for structural analysis of the molecular assembly formed by AmB based on solid-state NMR measurements.

Original language	English
Pages (from-to)	114-115
Number of pages	2
Journal	Chemistry Letters
Volume	38
Issue number	2
DOIs	https://doi.org/10.1246/cl.2009.114
Publication status	Published - Jul 20 2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.2009.114

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abstract = "A 13C-labeled amphotericin B (AmB) derivative was synthesized based on a hybrid strategy combining chemical synthesis with degradation of a natural product through successive cross-coupling reactions and macrolactonization. The specimen regiospecifically 13C-labeled (99% enrichment) at C25 position corresponding to the polyene moiety would be a powerful tool for structural analysis of the molecular assembly formed by AmB based on solid-state NMR measurements.",

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T2 - A molecular probe for solid-state NMR measurements

AU - Matsushita, Naohiro

AU - Matsuo, Yukiko

AU - Tsuchikawa, Hiroshi

AU - Matsumori, Nobuaki

AU - Murata, Michio

AU - Oishi, Tohru

PY - 2009/7/20

Y1 - 2009/7/20

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AB - A 13C-labeled amphotericin B (AmB) derivative was synthesized based on a hybrid strategy combining chemical synthesis with degradation of a natural product through successive cross-coupling reactions and macrolactonization. The specimen regiospecifically 13C-labeled (99% enrichment) at C25 position corresponding to the polyene moiety would be a powerful tool for structural analysis of the molecular assembly formed by AmB based on solid-state NMR measurements.

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JF - Chemistry Letters

IS - 2

ER -

Synthesis of 25- ¹³c-amphotericin B methyl ester: A molecular probe for solid-state NMR measurements

Abstract

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