Synthesis of 25- 13c-amphotericin B methyl ester: A molecular probe for solid-state NMR measurements

Naohiro Matsushita, Yukiko Matsuo, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata, Tohru Oishi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A 13C-labeled amphotericin B (AmB) derivative was synthesized based on a hybrid strategy combining chemical synthesis with degradation of a natural product through successive cross-coupling reactions and macrolactonization. The specimen regiospecifically 13C-labeled (99% enrichment) at C25 position corresponding to the polyene moiety would be a powerful tool for structural analysis of the molecular assembly formed by AmB based on solid-state NMR measurements.

Original languageEnglish
Pages (from-to)114-115
Number of pages2
JournalChemistry Letters
Issue number2
Publication statusPublished - Jul 20 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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