Synthesis of 28- 19 F-amphotericin B methyl ester

Hiroshi Tsuchikawa, Naohiro Matsushita, Nobuaki Matsumori, Michio Murata, Tohru Oishi

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35 Citations (Scopus)


A fluorinated amphotericin B (AmB) derivative, 28- 19 F-AmB methyl ester (3), labeled at the polyene moiety, was synthesized by combining chemical synthesis with degradation of a natural product via cross-coupling reactions and macrolactonization. The fluorinated derivative 3 showed antifungal activity similar to that of AmB, and is expected to be a powerful tool for NMR-based investigation of the mechanism of ion-channel formation.

Original languageEnglish
Pages (from-to)6187-6191
Number of pages5
JournalTetrahedron Letters
Issue number35
Publication statusPublished - Aug 28 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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