Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno; Ryosuke Shimizu; Ryohei Maeda; Ryoichi Kuwano

doi:10.1055/s-0031-1291146

Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno, Ryosuke Shimizu, Ryohei Maeda, Ryoichi Kuwano

Multidisciplinary chemistry

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

Original language	English
Pages (from-to)	1639-1642
Number of pages	4
Journal	Synlett
Volume	23
Issue number	11
DOIs	https://doi.org/10.1055/s-0031-1291146
Publication status	Published - Jun 15 2012

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All Science Journal Classification (ASJC) codes

Organic Chemistry

Cite this

Ueno, S., Shimizu, R., Maeda, R., & Kuwano, R. (2012). Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones. Synlett, 23(11), 1639-1642. https://doi.org/10.1055/s-0031-1291146

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10.1055/s-0031-1291146