Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno, Ryosuke Shimizu, Ryohei Maeda, Ryoichi Kuwano

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6 Citations (Scopus)

Abstract

o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

Original languageEnglish
Pages (from-to)1639-1642
Number of pages4
JournalSynlett
Volume23
Issue number11
DOIs
Publication statusPublished - Jun 15 2012

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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