Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno; Ryosuke Shimizu; Ryohei Maeda; Ryoichi Kuwano

doi:10.1055/s-0031-1291146

Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno, Ryosuke Shimizu, Ryohei Maeda, Ryoichi Kuwano

Multidisciplinary chemistry

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

Original language	English
Pages (from-to)	1639-1642
Number of pages	4
Journal	Synlett
Volume	23
Issue number	11
DOIs	https://doi.org/10.1055/s-0031-1291146
Publication status	Published - 2012

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1055/s-0031-1291146

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title = "Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones",

abstract = "o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.",

author = "Satoshi Ueno and Ryosuke Shimizu and Ryohei Maeda and Ryoichi Kuwano",

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AU - Ueno, Satoshi

AU - Shimizu, Ryosuke

AU - Maeda, Ryohei

AU - Kuwano, Ryoichi

PY - 2012

Y1 - 2012

N2 - o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

AB - o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

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ER -

Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Abstract

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