Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Manabu Nakazono, Shigeo Hasegawa, Tsuneyuki Yamamoto, Kiyoshi Zaitsu

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N′-di(1-adamantyl)malondiamide and C 60 in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10 mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.

Original languageEnglish
Pages (from-to)5619-5621
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number22
DOIs
Publication statusPublished - Nov 15 2004

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Fullerenes
Catalepsy
Haloperidol
Derivatives
61-bis(1-adamantylcarbamoyl)-1,2-methano(60)fullerene

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice. / Nakazono, Manabu; Hasegawa, Shigeo; Yamamoto, Tsuneyuki; Zaitsu, Kiyoshi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 22, 15.11.2004, p. 5619-5621.

Research output: Contribution to journal › Article

Nakazono, M, Hasegawa, S, Yamamoto, T & Zaitsu, K 2004, 'Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice', Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 22, pp. 5619-5621. https://doi.org/10.1016/j.bmcl.2004.08.053
Nakazono M, Hasegawa S, Yamamoto T, Zaitsu K. Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice. Bioorganic and Medicinal Chemistry Letters. 2004 Nov 15;14(22):5619-5621. https://doi.org/10.1016/j.bmcl.2004.08.053
Nakazono, Manabu ; Hasegawa, Shigeo ; Yamamoto, Tsuneyuki ; Zaitsu, Kiyoshi. / Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 22. pp. 5619-5621.
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