Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Manabu Nakazono; Shigeo Hasegawa; Tsuneyuki Yamamoto; Kiyoshi Zaitsu

doi:10.1016/j.bmcl.2004.08.053

Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Manabu Nakazono, Shigeo Hasegawa, Tsuneyuki Yamamoto, Kiyoshi Zaitsu

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N′-di(1-adamantyl)malondiamide and C ₆₀ in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10 mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.

Original language	English
Pages (from-to)	5619-5621
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2004.08.053
Publication status	Published - Nov 15 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.08.053

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title = "Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice",

abstract = "The 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene was synthesized from N,N′-di(1-adamantyl)malondiamide and C 60 in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene. The intraperitoneal administration of this fullerene derivative (10 mg/kg) caused an antagonistic effect on haloperidol-induced catalepsy in mice.",

author = "Manabu Nakazono and Shigeo Hasegawa and Tsuneyuki Yamamoto and Kiyoshi Zaitsu",

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AU - Nakazono, Manabu

AU - Hasegawa, Shigeo

AU - Yamamoto, Tsuneyuki

AU - Zaitsu, Kiyoshi

PY - 2004/11/15

Y1 - 2004/11/15

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice

Abstract

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