Synthesis of a bio-inspired catechol/phosphorylcholine surface modifier and characterization of its surface properties

Yucheng Zhang, Tomoyasu Hirai, Wei Ma, Yuji Higaki, Ken Kojio, Atsushi Takahara

Research output: Contribution to journalArticle

Abstract

Biocompatible and blood-compatible surface modification is urgently needed for stainless steel (SUS)-based human implant devices to avoid inflammation and biofouling. To this end, the use of polymeric surface modifiers, whose surface properties are specifically tailored, is a promising approach since this approach minimizes the impact on device's mechanical properties. However, adhesion between the device and surface modifier is relatively weak, since van der Waals forces are employed, leading to low device durability. To address this issue, this work functionalized poly(ɛ-caprolactone)-b-[poly(α-chloride-ɛ-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine)]2 (PCL-b-(PCL-Cl-b-PMPC)2) with catechol groups via a nucleophilic substitution, whereby the catechol functionalization was optimized. The resultant surface modifier showed strong adhesion toward SUS surfaces, forming a smooth and uniform hydrophilic polymeric film that reduced SUS fouling (i.e., protein). Notably, no significant changes of adhesion between the SUS and thin films (thin film) were observed after immersion for 45 days in a pH 7.4 phosphate buffer solution.

Original languageEnglish
Pages (from-to)38-49
Number of pages12
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Phosphorylcholine
Surface properties
Adhesion
Biofouling
Thin films
Van der Waals forces
Stainless Steel
Fouling
Polymer films
Surface treatment
Chlorides
Buffers
Phosphates
Durability
Blood
Substitution reactions
Stainless steel
Proteins
Mechanical properties
catechol

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

Synthesis of a bio-inspired catechol/phosphorylcholine surface modifier and characterization of its surface properties. / Zhang, Yucheng; Hirai, Tomoyasu; Ma, Wei; Higaki, Yuji; Kojio, Ken; Takahara, Atsushi.

In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 56, No. 1, 01.01.2018, p. 38-49.

Research output: Contribution to journalArticle

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