Abstract
Biocompatible and blood-compatible surface modification is urgently needed for stainless steel (SUS)-based human implant devices to avoid inflammation and biofouling. To this end, the use of polymeric surface modifiers, whose surface properties are specifically tailored, is a promising approach since this approach minimizes the impact on device's mechanical properties. However, adhesion between the device and surface modifier is relatively weak, since van der Waals forces are employed, leading to low device durability. To address this issue, this work functionalized poly(ɛ-caprolactone)-b-[poly(α-chloride-ɛ-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine)]2 (PCL-b-(PCL-Cl-b-PMPC)2) with catechol groups via a nucleophilic substitution, whereby the catechol functionalization was optimized. The resultant surface modifier showed strong adhesion toward SUS surfaces, forming a smooth and uniform hydrophilic polymeric film that reduced SUS fouling (i.e., protein). Notably, no significant changes of adhesion between the SUS and thin films (thin film) were observed after immersion for 45 days in a pH 7.4 phosphate buffer solution.
| Original language | English |
|---|---|
| Pages (from-to) | 38-49 |
| Number of pages | 12 |
| Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
| Volume | 56 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry
Cite this
Synthesis of a bio-inspired catechol/phosphorylcholine surface modifier and characterization of its surface properties. / Zhang, Yucheng; Hirai, Tomoyasu; Ma, Wei; Higaki, Yuji; Kojio, Ken; Takahara, Atsushi.
In: Journal of Polymer Science, Part A: Polymer Chemistry, Vol. 56, No. 1, 01.01.2018, p. 38-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of a bio-inspired catechol/phosphorylcholine surface modifier and characterization of its surface properties
AU - Zhang, Yucheng
AU - Hirai, Tomoyasu
AU - Ma, Wei
AU - Higaki, Yuji
AU - Kojio, Ken
AU - Takahara, Atsushi
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Biocompatible and blood-compatible surface modification is urgently needed for stainless steel (SUS)-based human implant devices to avoid inflammation and biofouling. To this end, the use of polymeric surface modifiers, whose surface properties are specifically tailored, is a promising approach since this approach minimizes the impact on device's mechanical properties. However, adhesion between the device and surface modifier is relatively weak, since van der Waals forces are employed, leading to low device durability. To address this issue, this work functionalized poly(ɛ-caprolactone)-b-[poly(α-chloride-ɛ-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine)]2 (PCL-b-(PCL-Cl-b-PMPC)2) with catechol groups via a nucleophilic substitution, whereby the catechol functionalization was optimized. The resultant surface modifier showed strong adhesion toward SUS surfaces, forming a smooth and uniform hydrophilic polymeric film that reduced SUS fouling (i.e., protein). Notably, no significant changes of adhesion between the SUS and thin films (thin film) were observed after immersion for 45 days in a pH 7.4 phosphate buffer solution.
AB - Biocompatible and blood-compatible surface modification is urgently needed for stainless steel (SUS)-based human implant devices to avoid inflammation and biofouling. To this end, the use of polymeric surface modifiers, whose surface properties are specifically tailored, is a promising approach since this approach minimizes the impact on device's mechanical properties. However, adhesion between the device and surface modifier is relatively weak, since van der Waals forces are employed, leading to low device durability. To address this issue, this work functionalized poly(ɛ-caprolactone)-b-[poly(α-chloride-ɛ-caprolactone)-b-poly(2-methacryloyloxyethyl phosphorylcholine)]2 (PCL-b-(PCL-Cl-b-PMPC)2) with catechol groups via a nucleophilic substitution, whereby the catechol functionalization was optimized. The resultant surface modifier showed strong adhesion toward SUS surfaces, forming a smooth and uniform hydrophilic polymeric film that reduced SUS fouling (i.e., protein). Notably, no significant changes of adhesion between the SUS and thin films (thin film) were observed after immersion for 45 days in a pH 7.4 phosphate buffer solution.
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UR - http://www.scopus.com/inward/citedby.url?scp=85030086908&partnerID=8YFLogxK
U2 - 10.1002/pola.28858
DO - 10.1002/pola.28858
M3 - Article
AN - SCOPUS:85030086908
VL - 56
SP - 38
EP - 49
JO - Journal of Polymer Science, Part A: Polymer Chemistry
JF - Journal of Polymer Science, Part A: Polymer Chemistry
SN - 0887-624X
IS - 1
ER -