Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Tsugumi Fujita, Takeru Nose, Ayami Matsushima, Kazushi Okada, Daisuke Asai, Yasuko Yamauchi, Naoto Shirasu, Takeshi Honda, Daiki Shigehiro, Yasuyuki Shimohigashi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A complete set of difluorophenylalanines in the L-configuration [L- (F2)Phe] (namely, L-(2,3-F2)Phe, L-(2,4-F2)Phe, L-(2,5-F2)Phe, L-(2,6- F2)Phe, L-(3,4-F2)Phe, L-(3,5-F2)Phe) was prepared and incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)923-927
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number6
DOIs
Publication statusPublished - Feb 5 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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