Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage

Ina L. Deras, Kaoru Takegawa, Akihiro Kondo, Ikunoshin Kato, Yuan C. Lee

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.

Original languageEnglish
Pages (from-to)1763-1766
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number13
DOIs
Publication statusPublished - Jul 7 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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