TY - JOUR
T1 - Synthesis of a novel ester analog of nucleic acids bearing a serine backbone
AU - Murata, Asako
AU - Wada, Takeshi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Sciences, and Technology, Japan. We are indebted to Professor K. Saigo for helpful suggestion.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - A novel analog of nucleic acids bearing an optically active serine ester backbone, serine-based nucleobase-linked polyester (SNE), was synthesized. Monomers containing a thymine base were synthesized from l- and d-serines. Furthermore, reaction conditions were thoroughly examined for the ester bond formation by using a new phosphonium-type condensing reagent on a solid support without racemization. The release of the dimer from the resin was also investigated using a new type of linker, which could be cleaved under neutral conditions.
AB - A novel analog of nucleic acids bearing an optically active serine ester backbone, serine-based nucleobase-linked polyester (SNE), was synthesized. Monomers containing a thymine base were synthesized from l- and d-serines. Furthermore, reaction conditions were thoroughly examined for the ester bond formation by using a new phosphonium-type condensing reagent on a solid support without racemization. The release of the dimer from the resin was also investigated using a new type of linker, which could be cleaved under neutral conditions.
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U2 - 10.1016/j.bmcl.2006.02.076
DO - 10.1016/j.bmcl.2006.02.076
M3 - Article
C2 - 16554150
AN - SCOPUS:33746626918
VL - 16
SP - 2933
EP - 2936
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 11
ER -