Synthesis of a novel ester analog of nucleic acids bearing a serine backbone

Asako Murata, Takeshi Wada

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A novel analog of nucleic acids bearing an optically active serine ester backbone, serine-based nucleobase-linked polyester (SNE), was synthesized. Monomers containing a thymine base were synthesized from l- and d-serines. Furthermore, reaction conditions were thoroughly examined for the ester bond formation by using a new phosphonium-type condensing reagent on a solid support without racemization. The release of the dimer from the resin was also investigated using a new type of linker, which could be cleaved under neutral conditions.

Original languageEnglish
Pages (from-to)2933-2936
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number11
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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