Synthesis of a trans-chelating chiral diphosphine ligand with only planar chirality and its application to asymmetric hydrosilylation of ketones

R. Kuwano, T. Uemura, M. Saitoh, Y. Ito

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69 Citations (Scopus)

Abstract

Optically active diphosphine (S,S)-2,2-bis[(diethylphosphino)methyl]- 1,1-biferrocene (abbreviated to (S,S)-EtTRAP-H) was synthesized from ferrocenyloxazoline derived from-L-valinol in 47% overall yield. The new chiral ligand, (S,S)-EtTRAP-H, which coordinates to a rhodium atom in a trans-chelating manner, was effective for asymmetric hydrosilylation of ketones to give optically active secondary alcohols with up to 94% ee.

Original languageEnglish
Pages (from-to)1327-1330
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number7
DOIs
Publication statusPublished - Feb 12 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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