Synthesis of amphiphilic lactose-substituted polyether dendrimers

Keigo Aoi, Takaaki Fukui, Yoshiharu Otsuka, Tadao Kondo, Keiji Tanaka, Toshihiko Nagamura

Research output: Contribution to conferencePaper

Abstract

Previously, we reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-acetyl-β-D- galactopyranosyl)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate followed by deacetylation. Chemical structures of the dendrimers were determined by1H-NMR, 1H-1H COSY and MALDI-TOF MS analyses.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

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Dendrimers
Polyethers
Sugars
Glycosylation
Polyethylene glycols
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Aoi, K., Fukui, T., Otsuka, Y., Kondo, T., Tanaka, K., & Nagamura, T. (2005). Synthesis of amphiphilic lactose-substituted polyether dendrimers. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.

Synthesis of amphiphilic lactose-substituted polyether dendrimers. / Aoi, Keigo; Fukui, Takaaki; Otsuka, Yoshiharu; Kondo, Tadao; Tanaka, Keiji; Nagamura, Toshihiko.

2005. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.

Research output: Contribution to conferencePaper

Aoi, K, Fukui, T, Otsuka, Y, Kondo, T, Tanaka, K & Nagamura, T 2005, 'Synthesis of amphiphilic lactose-substituted polyether dendrimers', Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan, 5/25/05 - 5/27/05.
Aoi K, Fukui T, Otsuka Y, Kondo T, Tanaka K, Nagamura T. Synthesis of amphiphilic lactose-substituted polyether dendrimers. 2005. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.
Aoi, Keigo ; Fukui, Takaaki ; Otsuka, Yoshiharu ; Kondo, Tadao ; Tanaka, Keiji ; Nagamura, Toshihiko. / Synthesis of amphiphilic lactose-substituted polyether dendrimers. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.1 p.
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AU - Tanaka, Keiji

AU - Nagamura, Toshihiko

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