Synthesis of amphiphilic polyether dendrimers having adamantyl groups

Takaaki Fukui, Keigo Aoi, Keiji Tanaka, Toshihiko Nagamura

Research output: Contribution to conferencePaper

Abstract

Our purpose is to create new biomedical materials with controlled sugar array having intervals on a nanoscale by organization. The plane arrangement of the dendrimers was shown to be able to control the intersugar distance at nano-level. We have already reported synthesis of amphiphilic aliphatic polyether dendrimers having a sugar residue at the core. In this report, we synthesized amphiphilic adamantyl-ended polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxyl-type adamantyl-terminal aliphatic polyether dendrimer and 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate or 4-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-D-glucopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 18 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period5/24/065/26/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Fukui, T., Aoi, K., Tanaka, K., & Nagamura, T. (2006). Synthesis of amphiphilic polyether dendrimers having adamantyl groups. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.