Synthesis of amphiphilic polyether dendrimers having adamantyl groups

Takaaki Fukui, Keigo Aoi, Keiji Tanaka, Toshihiko Nagamura

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    Our purpose is to create new biomedical materials with controlled sugar array having intervals on a nanoscale by organization. The plane arrangement of the dendrimers was shown to be able to control the intersugar distance at nano-level. We have already reported synthesis of amphiphilic aliphatic polyether dendrimers having a sugar residue at the core. In this report, we synthesized amphiphilic adamantyl-ended polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxyl-type adamantyl-terminal aliphatic polyether dendrimer and 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate or 4-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-D-glucopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.

    Original languageEnglish
    Number of pages1
    Publication statusPublished - Oct 18 2006
    Event55th SPSJ Annual Meeting - Nagoya, Japan
    Duration: May 24 2006May 26 2006

    Other

    Other55th SPSJ Annual Meeting
    Country/TerritoryJapan
    CityNagoya
    Period5/24/065/26/06

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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