Synthesis of anti-tubercular marine alkaloids denigrins A and B

Milandip Karak, Tohru Oishi, Kohei Torikai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The first synthesis of anti-tubercular marine alkaloids denigrins A and B were accomplished in three and five steps and 62% and 31% overall yields respectively, from maleic anhydride. The key features of the synthesis include efficient Mizoroki-Heck reaction, geometry-controlled vinylogous aldol condensation, and one-pot lactamization. The synthesis first demonstrates the serviceability of maleic anhydride in palladium-catalyzed cross-coupling reactions with diaryliodonium salt.

Original languageEnglish
Pages (from-to)2800-2803
Number of pages4
JournalTetrahedron Letters
Volume59
Issue number29
DOIs
Publication statusPublished - Jul 18 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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