Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

Mamiko Asano; Kazuo Harada; Tomoaki Yoshikawa; Takeshi Bamba; Kazumasa Hirata

doi:10.1271/bbb.90545

Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

Mamiko Asano, Kazuo Harada, Tomoaki Yoshikawa, Takeshi Bamba, Kazumasa Hirata

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

Original language	English
Pages (from-to)	386-389
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	2
DOIs	https://doi.org/10.1271/bbb.90545
Publication status	Published - 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.90545

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title = "Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature",

abstract = "We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.",

author = "Mamiko Asano and Kazuo Harada and Tomoaki Yoshikawa and Takeshi Bamba and Kazumasa Hirata",

year = "2010",

doi = "10.1271/bbb.90545",

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pages = "386--389",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

AU - Asano, Mamiko

AU - Harada, Kazuo

AU - Yoshikawa, Tomoaki

AU - Bamba, Takeshi

AU - Hirata, Kazumasa

PY - 2010

Y1 - 2010

N2 - We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

AB - We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

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U2 - 10.1271/bbb.90545

DO - 10.1271/bbb.90545

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SN - 0916-8451

VL - 74

SP - 386

EP - 389

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 2

ER -

Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

Abstract

All Science Journal Classification (ASJC) codes

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