Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

Mamiko Asano, Kazuo Harada, Tomoaki Yoshikawa, Takeshi Bamba, Kazumasa Hirata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number2
DOIs
Publication statusPublished - Mar 1 2010
Externally publishedYes

Fingerprint

Catharanthus
Indole Alkaloids
Ultraviolet Rays
Tumors
Irradiation
Flavin Mononucleotide
Temperature
Manganese
Neoplasms
Ions
catharanthine
vindoline
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature. / Asano, Mamiko; Harada, Kazuo; Yoshikawa, Tomoaki; Bamba, Takeshi; Hirata, Kazumasa.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 2, 01.03.2010, p. 386-389.

Research output: Contribution to journalArticle

@article{e47d801fa9aa4d148bed3c08d0361d32,
title = "Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature",
abstract = "We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.",
author = "Mamiko Asano and Kazuo Harada and Tomoaki Yoshikawa and Takeshi Bamba and Kazumasa Hirata",
year = "2010",
month = "3",
day = "1",
doi = "10.1271/bbb.90545",
language = "English",
volume = "74",
pages = "386--389",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "2",

}

TY - JOUR

T1 - Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

AU - Asano, Mamiko

AU - Harada, Kazuo

AU - Yoshikawa, Tomoaki

AU - Bamba, Takeshi

AU - Hirata, Kazumasa

PY - 2010/3/1

Y1 - 2010/3/1

N2 - We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

AB - We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

UR - http://www.scopus.com/inward/record.url?scp=77249124354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77249124354&partnerID=8YFLogxK

U2 - 10.1271/bbb.90545

DO - 10.1271/bbb.90545

M3 - Article

VL - 74

SP - 386

EP - 389

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 2

ER -