Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

Mamiko Asano, Kazuo Harada, Tomoaki Yoshikawa, Takeshi Bamba, Kazumasa Hirata

Research output: Contribution to journalArticle

6 Citations (Scopus)


We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number2
Publication statusPublished - Mar 1 2010
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this