Synthesis of chiral 2,3-disubstituted 1,4-diazabicyclo [2.2.2] octane. New ligand for the osmium-catalyzed asymmetric dihydroxylation of olefins

Tohru Oishi, Masahiro Hirama

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54 Citations (Scopus)

Abstract

Chiral 2,3-disubstituted 1,4-diazabicyclo[2.2.2]octane (DABCO) derivatives have been synthesized and utilized as a chiral ligand for the osmium-catalyzed asymmetric dihydroxylation of olefins. Optically active diols in up to 41%ee are obtained in good yields.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number5
DOIs
Publication statusPublished - Jan 28 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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