@article{7567951d8f29413dbb7211cf8ec73762,
title = "Synthesis of CH2-linked α-galactosylceramide and its glucose analogues through glycosyl radical-mediated direct: C -glycosylation",
abstract = "We describe a new synthetic approach for C-linked glycolipid analogues, in which the cleavable O-glycosidic linkage is replaced by a carbon unit. Direct C-glycosylation of a conformationally constrained and stable C1-sp3 hybridized xanthate carbohydrate with carefully designed sphingosine units afforded the CH2-linked analogue of antitumor-active KRN7000 and its glucose congener.",
author = "Yu Hidaka and Noriaki Kiya and Makoto Yoritate and Kazuteru Usui and Go Hirai",
note = "Funding Information: This study was partially supported by PRIME (Grant Number JP19gm5910018) and the Platform Project for Supporting Drug Discovery and Life Science Research (BINDS, Grant Number JP18am0101091) from the Japan Agency for Medical Research and development, AMED, the JSPS KAKENHI (Grant Numbers 16H01167 and 18H04417 for Middle Molecular Strategy and 18H02097), JSPS A3 Foresight Program, and the Fukuoka Foundation for Sound Health Cancer Research Fund (for K. U.). We also thank Dr Tatsuya Uchida (Kyushu University, Japan) for his support. The computations were performed at the Research Institute for Information Technology, Kyushu University.",
year = "2020",
month = apr,
day = "30",
doi = "10.1039/d0cc00785d",
language = "English",
volume = "56",
pages = "4712--4715",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "34",
}