Synthesis of cycloalkyl/steroidal heteroaryl sulfides using rhodium-catalyzed heteroaryl exchange reaction

Mieko Arisawa, Katsuya Nakai, Tomoki Yamada, Ren Suzuki, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cycloalkyl heteroaryl sulfides are efficiently synthesized by the single-bond cleavage and exchange reaction of S-cycloalkyl thioesters and heteroaryl ethers without using a base. The method is applicable to steroids at the A- and D-rings, and provides diverse heteroarylthiolated steroids with five- and six-membered heteroarenes.

Original languageEnglish
Pages (from-to)104-118
Number of pages15
JournalHeterocycles
Volume100
Issue number1
DOIs
Publication statusPublished - 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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