Synthesis of endogenous sperm-activating and attracting factor isolated from ascidian Ciona intestinalis

Tohru Oishi, Hiroshi Tsuchikawa, Michio Murata, Manabu Yoshida, Masaaki Morisawa

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

A chemoattractant candidate named sperm-activating and attracting factor (SAAF) from the eggs of ascidian Ciona intestinalis, was synthesized from chenodeoxycholic acid in 16 steps. The present synthesis led to the unambiguous structure determination of SAAF to be (3R,4R,7R,25S)-3,4,7,26-tetrahydroxycholestane-3,26-disulfate. The synthetic pure specimen was also used to confirm the dual sperm-activating and attracting activity.

Original languageEnglish
Pages (from-to)6387-6389
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number34
DOIs
Publication statusPublished - Aug 18 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of endogenous sperm-activating and attracting factor isolated from ascidian Ciona intestinalis'. Together they form a unique fingerprint.

Cite this