Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control

Keiko Terada, Yuko Sato, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to conferencePaper

Abstract

We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Terada, K., Sato, Y., Mori, T., Niidome, T., & Katayama, Y. (2006). Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.