Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control

Keiko Terada, Yuko Sato, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to conferencePaper

Abstract

We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

Fingerprint

Genes
Gene expression
Peptides
Cells
Polymers
Substrates

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Terada, K., Sato, Y., Mori, T., Niidome, T., & Katayama, Y. (2006). Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control. / Terada, Keiko; Sato, Yuko; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki.

2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.

Research output: Contribution to conferencePaper

Terada, K, Sato, Y, Mori, T, Niidome, T & Katayama, Y 2006, 'Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control' Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan, 9/20/06 - 9/22/06, .
Terada K, Sato Y, Mori T, Niidome T, Katayama Y. Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control. 2006. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.
Terada, Keiko ; Sato, Yuko ; Mori, Takeshi ; Niidome, Takuro ; Katayama, Yoshiki. / Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.1 p.
@conference{35a8cd7ad2c0413bb4d7fda254531767,
title = "Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control",
abstract = "We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.",
author = "Keiko Terada and Yuko Sato and Takeshi Mori and Takuro Niidome and Yoshiki Katayama",
year = "2006",
month = "12",
day = "1",
language = "English",
note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control

AU - Terada, Keiko

AU - Sato, Yuko

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Katayama, Yoshiki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.

AB - We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.

UR - http://www.scopus.com/inward/record.url?scp=33846124999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846124999&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846124999

ER -