Synthesis of gene carriers responding to tyrosine kinase 'c-Src' and their functional control

Keiko Terada, Yuko Sato, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    We designed gene carriers that can activate the delivered gene in response to the intercellular kinase signal. 'c-Src', which is a non-receptor tyrosine kinase, is specifically activated within a cancer cell. Our goal is to create various gene carriers to express a therapeutic gene in response to 'c-Src' activity. First, we synthesized some polymers that are grafted with c-Src substrate peptides as an intercellular signal-response gene carrier. Then, we evaluated whether those carriers can regulate gene expression in cell free system. We will discuss the relation between the carrier design and their abilities for signal specific gene regulation.

    Original languageEnglish
    Number of pages1
    Publication statusPublished - Dec 1 2006
    Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
    Duration: Sep 20 2006Sep 22 2006

    Other

    Other55th Society of Polymer Science Japan Symposium on Macromolecules
    CountryJapan
    CityToyama
    Period9/20/069/22/06

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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