Synthesis of Glycopolymers Carrying 3'-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E

Takato Ishida; Masanori Nagao; Takahiro Oh; Takeshi Mori; Yu Hoshino; Yoshiko Miura

doi:10.1246/cl.210740

Synthesis of Glycopolymers Carrying 3'-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E

Takato Ishida, Masanori Nagao, Takahiro Oh, Takeshi Mori, Yu Hoshino, Yoshiko Miura

Research output: Contribution to journal › Article › peer-review

Abstract

One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).

Original language	English
Pages (from-to)	308-311
Number of pages	4
Journal	Chemistry Letters
Volume	51
Issue number	3
DOIs	https://doi.org/10.1246/cl.210740
Publication status	Published - Mar 2022

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.210740

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title = "Synthesis of Glycopolymers Carrying 3'-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E",

abstract = "One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).",

author = "Takato Ishida and Masanori Nagao and Takahiro Oh and Takeshi Mori and Yu Hoshino and Yoshiko Miura",

note = "Funding Information: This work was supported by a JSPS KAKENHI Grant Number JP20H05230, JP20H04825, and JP19H02766. We also thank Mr. Hiroki Takeuchi, Mr. Yunosuke Oshiro, Mr. Kazuki Nobuhiro, and Dr. Hirohiko Ise (Kyusyu University) for the great help. Publisher Copyright: {\textcopyright} 2022 The Chemical Society of Japan",

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AU - Ishida, Takato

AU - Nagao, Masanori

AU - Oh, Takahiro

AU - Mori, Takeshi

AU - Hoshino, Yu

AU - Miura, Yoshiko

N1 - Funding Information: This work was supported by a JSPS KAKENHI Grant Number JP20H05230, JP20H04825, and JP19H02766. We also thank Mr. Hiroki Takeuchi, Mr. Yunosuke Oshiro, Mr. Kazuki Nobuhiro, and Dr. Hirohiko Ise (Kyusyu University) for the great help. Publisher Copyright: © 2022 The Chemical Society of Japan

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N2 - One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).

AB - One of the new strategies to treat autoimmune diseases is to target Siglec, a membrane protein receptor with the ability to suppress immune responses. Herein, we synthesized glycopolymers carrying 3'-sialyllactose in various glycounit densities. RAW 264.7 macrophages transfected to express secreted alkaline phosphatase (SEAP) were used to evaluate the immunosuppression ability of the glycopolymers. The inhibition of the signal transmission was dependent on the glycounit densities of the glycopolymers, and was maximized at the moderate density (70%).

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Synthesis of Glycopolymers Carrying 3'-Sialyllactose for Suppressing Inflammatory Reaction via Siglec-E

Abstract

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