Synthesis of Novel Monobactams Bearing an (R)-1-Hydroxyethyl Group and an (S)-1-Carbamoy1-oxyethyl Group at the C3 4-Positions

Kikoh Obi, Yoshio Ito, Shiro Terashima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Various structural types of monobactams bearing an (R)-1-hydroxyethyl and an (S)-I.-carbamoyloxyethyl group at the C3,4-positions, respectively, could be synthesized from (3S,4S)-4-[(S)-l-benzyloxyethyl]-3-[(R)-l-hydroxyethyl]-2-azetidinone. These synthetic studies explored several novel methods applicable to construct substituted carbamoyloxy groups.

Original languageEnglish
Pages (from-to)917-924
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number4
DOIs
Publication statusPublished - Jan 1 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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