Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Mariko Aso, Mitsuhiro Fukuda, Kazuteru Usui, Hiroshi Suemune

Research output: Contribution to journalMeeting Abstract

Abstract

We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

Original languageEnglish
Pages (from-to)59-60
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number48
Publication statusPublished - 2004

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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