Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Mariko Aso; Mitsuhiro Fukuda; Kazuteru Usui; Hiroshi Suemune

Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Mariko Aso, Mitsuhiro Fukuda, Kazuteru Usui, Hiroshi Suemune

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Meeting Abstract

Abstract

We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

Original language	English
Pages (from-to)	59-60
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	48
Publication status	Published - 2004

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

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title = "Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.",

abstract = "We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.",

author = "Mariko Aso and Mitsuhiro Fukuda and Kazuteru Usui and Hiroshi Suemune",

year = "2004",

language = "English",

pages = "59--60",

journal = "Nucleic acids symposium series (2004)",

issn = "1746-8272",

publisher = "Oxford University Press",

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T1 - Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

AU - Aso, Mariko

AU - Fukuda, Mitsuhiro

AU - Usui, Kazuteru

AU - Suemune, Hiroshi

PY - 2004

Y1 - 2004

N2 - We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

AB - We synthesized oligonucleotide (1) containing 4'-o-nitrobenzyloxythymidine (2), which was prepared by reaction of 4',5'-unsaturated thymidine with m-CPBA followed by Lewis-acid catalyzed addition of o-nitrobenzylalcohol. The duplex stability of 1 with the complementary oligonucleotide was studied by Tm measurement. Photochemical reaction of 1 to generate C4'-oxidized abasic site containing oligonucleotide (3) was studied.

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M3 - Meeting Abstract

C2 - 17150477

AN - SCOPUS:36048961098

SN - 1746-8272

SP - 59

EP - 60

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 48

ER -

Synthesis of oligonucleotide containing 4'-o-nitrobenzyloxythymidine and its reactivity.

Abstract

All Science Journal Classification (ASJC) codes

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