Synthesis of pectin-N, N-dimethyl acrylamide hydrogel by gamma radiation and application in drug delivery (in vitro)

Md Murshed Bhuyan, Hirotaka Okabe, Yoshiki Hidaka, Nirmal Chandra Dafader, Nazia Rahman, Kazuhiro Hara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The objective of the work is to synthesize pectin-N, N-Dimethylacrylamide (DMAA) hydrogel by gamma radiation without using any initiators and cross-linking agents. Effect of radiation doses on gel fraction and equilibrium swelling as a function of pH were studied, and 5 kGy radiation dose was found to be the optimum dose for hydrogel synthesis. The grafting /crosslinking was investigated by Fourier transform infrared spectroscopy. Thermal properties and surface morphology were studied by differential scanning calorimetry and scanning electron microscopy. To study the drug release kinetics, 5-fluorouracil was loaded into the hydrogel and in vitro release was carried out in simulated gastric and intestinal fluid. The release profile of drug showed that more than 90% of the loaded drugs were released after 4 hours at both gastric fluid and intestinal fluid pH. Drug release data was fitted into zero order, Higuchi and Korsmeyer-Peppas kinetic models. Higuchi model was found to be the best fitted and release exponent ‘n’ value of Korsmeyer-Peppas model indicated the non-Fickian transport.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalJournal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume55
Issue number4
DOIs
Publication statusPublished - Apr 3 2018

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Acrylamide
Hydrogel
Drug delivery
Hydrogels
Gamma rays
Dosimetry
Fluids
Pharmaceutical Preparations
Kinetics
Crosslinking
Fourier transform infrared spectroscopy
Surface morphology
Swelling
Differential scanning calorimetry
Thermodynamic properties
Gels
Fluorouracil
Scanning electron microscopy
pectin

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Synthesis of pectin-N, N-dimethyl acrylamide hydrogel by gamma radiation and application in drug delivery (in vitro). / Bhuyan, Md Murshed; Okabe, Hirotaka; Hidaka, Yoshiki; Dafader, Nirmal Chandra; Rahman, Nazia; Hara, Kazuhiro.

In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 55, No. 4, 03.04.2018, p. 369-376.

Research output: Contribution to journalArticle

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AU - Rahman, Nazia

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